Approaches to Test the Neurotoxicity of Environmental Contaminants in the Zebrafish Model: From Behavior to Molecular Mechanisms.

摘要: The occurrence of neuroactive chemicals in the aquatic environment is on rise and poses a potential threat to biota currently unpredictable outcome. In particular, subtle changes caused by these an organism's sensation or behavior are difficult tackle with current test systems that focus rodents vitro omit whole-animal responses. recent years, zebrafish (Danio rerio) has become popular model organism for toxicological studies testing strategies, such as standardized use early life stages Organisation Economic Co-operation Development's guideline 236. terms neurotoxicity, provides powerful investigate nervous system from several different angles, offering ability mechanisms action detail. mechanistic understanding gained through analysis this species good basic knowledge how might interact teleost system. Such information can help infer effects occurring other exposed their predicting risks chemical ecosystem. present article, we highlight approaches ranging behavioral structural, functional, molecular larval system, providing holistic view neurotoxic outcomes. Environ Toxicol Chem 2021;40:989-1006. © 2020 SETAC.