Critical limb ischaemia: initial treatment and predictors of amputation-free survival.

摘要: Abstract Objectives To evaluate initial treatment and risk factors for amputation-free survival in patients with critical limb ischaemia (CLI). Design Prospective clinical cohort study at a single vascular surgical centre Germany. Methods Data on 104 consecutive (115 ischaemic limbs) presenting their first episode of CLI were collected prospectively over 3-year period. Initial was classified as conservative therapy, intervention, surgery, or major amputation. Patient co-morbidities assessed by uni- multivariate analysis to determine salvage, survival. Results Indications rest pain 27 (23.5%) tissue loss 88 (76.5%) limbs. Revascularisation attempted 65% all limbs: 45% intervention 55% surgery. In 9% primary amputation necessary 22% received therapy. Median follow-up 28 months (1–42). The patient survival, rates 73%, 41%, 31%, respectively. Diabetes, cardiac disease renal insufficiency associated poor Combined adversely affected (HR, 3.68; 95% CI, 1.51–8.94; P Conclusions At least two third can be offered some type direct revascularisation. insufficiency, outcome terms is anticipated.