Prognostic role of lncRNA HOTAIR in esophageal squamous cell carcinoma.
作者： Wei Song , Shu-bing Zou
DOI: 10.1016/J.CCA.2016.10.035
关键词:
摘要: Abstract Background HOX transcript antisense intergenic RNA (HOTAIR) may be implicated in cancer development and progression. Clinical studies have suggested that HOTAIR related to poor prognosis esophageal squamous cell carcinoma (ESCC). This study was designed clarify the prognostic role of ESCC. Methods MEDLINE, EMBASE, Cochrane Central Register Controlled Trials, China National Knowledge Infrastructure (CNKI) databases were searched identify evaluating significance Pooled hazard ratios (HRs) for overall survival (OS), lymph node metastasis (LNM), stage calculated using fixed-effects/random-effects models. Results A total 510 patients from five included. Meta-analysis revealed high expression significantly correlated with OS (HR, 2.37; 95% CI, 1.80–3.11; P Conclusion Elevated lncRNA indicated a ESCC, it also predictive potential ESCC metastasis.
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