Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
作者： Ryan D Morin , Maria Mendez-Lago , Andrew J Mungall , Rodrigo Goya , Karen L Mungall
DOI: 10.1038/NATURE10351
关键词:
摘要: Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in …
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