Prevalence of IgA-antiendomysial antibody in asymptomatic low bone mineral density

摘要: Abstract OBJECTIVE: Celiac disease (CD) is a relatively common gastrointestinal disorder that can be asymptomatic. However, even among asymptomatic patients long-term reduction in bone mineral density (BMD) found. Excellent noninvasive screening tests for CD are now available. Studies using older techniques have suggested 10-fold increased prevalence of with low BMD, but this has not been confirmed current testing methodology. We set out to confirm these estimates antiendomysial antibody testing. METHODS: A total 100 consecutive referred our outpatient endocrinology clinic evaluation idiopathic BMD were studied. In addition the routine evaluation, completed symptom questionnaire and underwent serological presence IgA (EMA). All positive EMA small bowel biopsy permeability studies. RESULTS: results available on 96 patients; 78/96 female mean age was 57 yr (range 18–86 yr). Seven (7.3% [95% CI 2.1–12.5%]) EMA-positive, all titer (≤1:20). none biopsies showed any histopathological features CD, nor did status correlate clinical or laboratory assessed. CONCLUSIONS: Despite high rate weakly tests, data do support an BMD. Without increase over background prevalence, cost argues against use test population.