Pathologic stage I non-small cell lung cancer with high levels of preoperative serum carcinoembryonic antigen: clinicopathologic characteristics and prognosis.

摘要: Objective Surgery alone remains the standard therapy for patients with stage I non–small cell lung cancer. Although preoperative serum level of carcinoembryonic antigen has been shown to be an independent prognostic factor, it not yet included in staging system and does alter treatment strategy, especially selection adjuvant chemotherapy. Methods From 1986 2003, postoperative levels were measured 455 completely resected pathologic We compared clinicopathologic characteristics outcomes among who had within normal range (N group, n=323), high before surgery but after (HN n=112), (HH n=20). Results The significant HN group male sex, greater age, smoking, squamous histology, T2 status, lymphatic invasion, vascular pleural invasion. Adenocarcinomas more likely moderately poorly differentiated. 5-year survivals HH groups significantly lower (56.2% 43.1%, respectively) than those N (85.9%). Multivariate analysis revealed that non-adenocarcinoma factors. Conclusion Patients cancer are a subgroup distinctly poor prognosis display smoking-related characteristics.