Prognostic Significance of Pretreatment Squamous Cell Carcinoma Antigen and Carcinoembryonic Antigen in Squamous Cell Carcinoma of the Uterine Cervix
作者： Seog Nyeon Bae , Sung Eun Namkoong , Jae Keun Jung , Chan Joo Kim , Jong Sup Park
关键词:
摘要: Sixty-seven patients with squamous cell carcinoma of the uterine cervix (FIGO Stages IB2, IIA, and IIB) were reviewed to evaluate pretreatment level antigen (SCC) carcinoembryonic (CEA) which may be used predict a subset poor prognosis. The rate pathologic serum SCC increased significantly in cases Stage IIB compared that IB2 IIA (50% versus 16.3%). CEA did not show any difference between these two groups (29.2% 30.2%). 48-month disease-free survival for levels one or both tumor-associated antigens (TAAs) was 40.0% 91.7% normal (log-rank test, P < 0.005) IIA. Patients who had TAAs showed higher incidence lymph node metastasis than (36.7% 10.8%). have poorest make it possible clinical response neoadjuvant chemotherapy consisting cis-platinum (DDP) 5-fluorouracil (5-FU). Our findings suggest conjunction is valuable tumor marker prognosis foresee subsequent chemotherapy.
gynecologiconcology-online.net
elsevier.com
sci-hub.se 参考文章(42)
Soo Keat Khoo, Brian Daunter, Eric Mackay, Carcinoembryonic Antigen and β2‐Microglobulin as Serum Tumor Markers in Women with Genital Cancer International Journal of Gynecology & Obstetrics. ,vol. 16, pp. 388- 393 ,(1979) , 10.1002/J.1879-3479.1979.TB00471.X
Hiroshi Kato, Hitoshi Morioka, Shojiro Aramaki, Kazunori Tamai, Tadashi Torigoe, Prognostic significance of the tumor antigen TA-4 in squamous cell carcinoma of the uterine cervix American Journal of Obstetrics and Gynecology. ,vol. 145, pp. 350- 354 ,(1983) , 10.1016/0002-9378(83)90723-8
John R. van Nagell, J.W. Roddick, D.M. Lowin, The staging of cervical cancer: Inevitable discrepancies between clinical staging and pathologic findings American Journal of Obstetrics and Gynecology. ,vol. 110, pp. 973- 978 ,(1971) , 10.1016/0002-9378(71)90551-5
Sung Eun Namkoong, Jong Sup Park, Jin Woo Kim, Seog Nyeon Bae, Gu Taek Han, Joon Mo Lee, Jae Keun Jung, Seung Jo Kim, Comparative study of the patients with locally advanced stages I and II cervical cancer treated by radical surgery with and without preoperative adjuvant chemotherapy. Gynecologic Oncology. ,vol. 59, pp. 136- 142 ,(1995) , 10.1006/GYNO.1995.1280
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
S. K. Khoo, E. V. Mackay, Carcinoembryonic Antigen in Cancer of the Female Reproductive System Sequential Levels and Effects of Treatment Australian & New Zealand Journal of Obstetrics & Gynaecology. ,vol. 13, pp. 1- 7 ,(1973) , 10.1111/J.1479-828X.1973.TB02270.X
Dale M. Larson, Larry J. Copeland, C.Allen Stringer, David M. Gershenson, John M. Malone, Creighton L. Edwards, Recurrent cervical carcinoma after radical hysterectomy Gynecologic Oncology. ,vol. 30, pp. 381- 387 ,(1988) , 10.1016/0090-8258(88)90252-1
H-B. Krebs, B.F. Helmkamp, B-U. Sevin, M. Nadji, H.E. Averette, Recurrent cancer of the cervix following radical hysterectomy and pelvic node dissection Gynecologic Oncology. ,vol. 10, pp. 364- ,(1980) , 10.1016/0090-8258(80)90125-0
HISAO ITO, SOJU KURIHARA, CHIAKI NISHIMURA, Serum carcinoembryonic antigens in patients with carcinoma of the cervix. Obstetrics & Gynecology. ,vol. 51, pp. 468- 471 ,(1978) , 10.1097/00006250-197804000-00017
Peter G. Rose, Stephen Baker, Lawrence Fournier, Beth E. Nelson, Richard E. Hunter, Serum squamous cell carcinoma antigen levels in invasive cervical cancer: Prediction of response and recurrence American Journal of Obstetrics and Gynecology. ,vol. 168, pp. 942- 946 ,(1993) , 10.1016/S0002-9378(12)90850-9