Blood vessel invasion by tumor cells predicts recurrence in completely resected T1 N0 M0 non-small-cell lung cancer.

摘要: The prognostic significance of traditional and newer tumor cell-related biologic parameters, like deoxyribonucleic acid ploidy (flow cytometry), proliferative activity (expression proliferating cell nuclear antigen by immunohistochemistry), mitotic count, intratumoral or peritumoral (or both) blood lymphatic vessel invasion cells was investigated in 95 consecutive patients who had T1 N0 M0 non-small-cell lung cancer operation alone between 1975 1985. median follow-up for the entire group is now 8.3 years, overall 5-, 10-, 15-year-survivals were 75%, 69%, 61%, respectively. Twenty-two died either local (n = 3) systemic 19) recurrent cancer, 5 non-cancer-related causes, 2 new primary 1 an extrathoracic cancer. By multivariate analysis, (p 0.0001) count 0.016) independent predictors survival; contrast, disease-free survival influenced only 0.0004). relative risk death low-risk 79) 13.3 (95% confidence interval, 6.1 to 28.7) times lower than that high-risk 16) horac C ardiovasc S urg 1993;106:80-9)