Mice that make VL binding proteins
作者： Andrew J. Murphy , Karolina A. Hosiawa , Cagan Gurer , Sean Stevens , Lynn MacDonald
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摘要: Genetically modified mice and methods for making an using them are provided, wherein the comprise a replacement of all or substantially immunoglobulin heavy chain V gene segments, D J segments with at least one light segment segment. Mice that make binding proteins variable domain operably linked to constant region provided. Binding contain domain, including somatically hypermutated fused region, Modified cells, embryos, encode sequences
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