Harnessing the Power of Posttranscriptional Gene Silencing in Crohn’s Disease

摘要: Posttranscriptional gene silencing or RNA interference is a mechanism by which the expression of one more genes partially fully suppressed noncoding RNAs, particularly small RNAs. In laboratory this concept has been utilized to introduce synthetic anti-microRNA (miRNA) oligonucleotides downregulate completely abrogate expression. MiRNAs are group (~22 nucleotide), RNAs that confer such posttranscriptional regulation expression.1 They have emerged as key regulators wide variety biological processes and also candidate therapeutic targets. silence binding target sites found within 3′untranslated region (UTR) targeted mitochondrial RNA. This results in suppression protein synthesis and/or degradation transcript. A number miRNAs already identified pathways underlie pathogenesis Crohn's Disease (CD).2 For example, miR-192, miR-122, miR-29, miR-146a shown repress NOD2, implicated CD.3, 4, 5, 6 Using RNA-sequencing suite were colon tissue stratify CD patients according disease behavior independent effect inflammation. Furthermore, levels specific these could predict progression penetrating fistulizing CD.7 The purpose short review highlight advances using understanding treating CD.8, 9