Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease.

作者: Giovanni Monteleone , Massimo C Fantini , Sara Onali , Francesca Zorzi , Giulia Sancesario

DOI: 10.1038/MT.2011.290

关键词:

摘要: … colitis, 13 thus suggesting that Smad7 is a tractable target in CD. … Smad7 in humans. Data suggest that oral administration of Smad7 antisense oligonucleotide to patients with active CD …

参考文章(24)
M. A. Smith, P. M. Irving, A. M. Marinaki, J. D. Sanderson, Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease. Alimentary Pharmacology & Therapeutics. ,vol. 32, pp. 119- 130 ,(2010) , 10.1111/J.1365-2036.2010.04330.X
G Monteleone, M Boirivant, F Pallone, T T MacDonald, TGF-β1 and Smad7 in the regulation of IBD Mucosal Immunology. ,vol. 1, ,(2008) , 10.1038/MI.2008.55
Konstantinos A. Papadakis, John Prehn, Sofia T. Moreno, Lorna Cheng, Elias A. Kouroumalis, Richard Deem, Tim Breaverman, Paul D. Ponath, David P. Andrew, Peter H.R. Green, Martin R. Hodge, Scott W. Binder, Stephan R. Targan, CCR9–Positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease ☆ ☆☆ Gastroenterology. ,vol. 121, pp. 246- 254 ,(2001) , 10.1053/GAST.2001.27154
Thomas T MacDonald, Giovanni Monteleone, Immunity, Inflammation, and Allergy in the Gut Science. ,vol. 307, pp. 1920- 1925 ,(2005) , 10.1126/SCIENCE.1106442
Monica Boirivant, Francesco Pallone, Claudia Di Giacinto, Daniele Fina, Ivan Monteleone, Mariarosaria Marinaro, Roberta Caruso, Alfredo Colantoni, Giampiero Palmieri, Massimo Sanchez, Warren Strober, Thomas T. MacDonald, Giovanni Monteleone, Inhibition of Smad7 With a Specific Antisense Oligonucleotide Facilitates TGF-β1–Mediated Suppression of Colitis Gastroenterology. ,vol. 131, pp. 1786- 1798 ,(2006) , 10.1053/J.GASTRO.2006.09.016
Lukas J. A. C. Hawinkels, Peter ten Dijke, Exploring anti-TGF-β therapies in cancer and fibrosis Growth Factors Journal. ,vol. 29, pp. 140- 152 ,(2011) , 10.3109/08977194.2011.595411
Kevin J. Maloy, Fiona Powrie, Intestinal homeostasis and its breakdown in inflammatory bowel disease Nature. ,vol. 474, pp. 298- 306 ,(2011) , 10.1038/NATURE10208
Giovanni Monteleone, Andrea Kumberova, Nicholas M. Croft, Catriona McKenzie, Howard W. Steer, Thomas T. MacDonald, Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease Journal of Clinical Investigation. ,vol. 108, pp. 601- 609 ,(2001) , 10.1172/JCI12821
Masahiko Mihara, Misato Hashizume, Hiroto Yoshida, Miho Suzuki, Masashi Shiina, IL-6/IL-6 receptor system and its role in physiological and pathological conditions Clinical Science. ,vol. 122, pp. 143- 159 ,(2012) , 10.1042/CS20110340
Juan F. Santibañez, Miguel Quintanilla, Carmelo Bernabeu, TGF-β/TGF-β receptor system and its role in physiological and pathological conditions Clinical Science. ,vol. 121, pp. 233- 251 ,(2011) , 10.1042/CS20110086