Treatment of Angina Pectoris with Calcium Antagonists: Long-Term Follow-up

摘要: This study was designed to investigate the association of calcium channel blocker (CCB) use with subsequent mortality in a group patients chronic stable angina. CCBs have been proven effective treatment angina pectoris. Recently, safety hypertensive and coronary artery disease has challenged. New prospective controlled studies nifedipine are under way that may help define long-term these patients. Until concluded, data on among CCB users be informative. From 1990 1992, 11,575 heart were screened but not included secondary prevention bezafibrate conducted 18 cardiac departments Israel. Of patients, 2390 had without history myocardial infarction followed for over 4–6 years (mean 5.2 years). this patient population, 1366 (57%) reported receiving CCB. They more women hypertensives, greater proportion them exhibited higher severity anginal class than counterparts treated (n = 1024). The similar those (11.5% vs. 11.6%; P 0.53). A multivariate analysis accounting differences age, sex, other clinical parameters associated increased risk evaluated estimated hazard ratio (HR) death compared (HR 0.89; 95% Cl 0.68–1.16). In Cox regression analysis, adjusted HR or diltiazem, together beta-blocker, 0.85 (95% 0.47–1.54) 0.47 0.24–0.90), respectively. After follow-up 5.2) there no evidence However, due wide confidence intervals possible confounding factors, randomized control required provide definitive information.