Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.

摘要: Aims Colorectal carcinoma (CRC) with micropapillary (MP) features has only been recently described and is still being characterized. Methods Results We reviewed the clinicopathologic molecular of 42 CRC MP features. Twenty-nine cases were also evaluated for immunohistochemical evidence epithelial-mesenchymal transition (EMT). The extent within our cohort ranged from 5% (13 cases) to 100% (1 case). Twenty-seven featured prominent cribriforming dirty necrosis in non-MP component; nine displayed mucinous Twenty-four 29 (83%) demonstrated EMT. Thirty-six (86%) showed advanced T-category (pT3 or pT4), 31 (74%) had lymph node metastases, 23 (55%) distant metastases. Median overall follow-up was 36 months. Seventeen patients (40%) died disease, median survival Mutations seen 17 tested (55%), including 11 KRAS mutations 4 BRAF V600E mutations. Microsatellite instability testing performed on 21 cases; all microsatellite-stable. Compared a 972 conventional CRC, more likely present as Stage IV disease (P<0.001), but no significant differences after adjusting stage. Conclusions MP portend high likelihood local often associated cribriform pattern elsewhere tumour cystic nodal metastases necrosis. They show frequent BRAF. Immunohistochemical EMT common CRC. This article protected by copyright. All rights reserved.