Variability in responsiveness to clopidogrel in patients with intermittent claudication.

摘要: Abstract Objective The concept of clopidogrel resistance is frequently evoked in the cardiac literature. variability antiplatelet response patients with intermittent claudication has not been investigated. aim this study was to describe effect addition aspirin using ex vivo measures platelet activation life-style limiting claudication. Design Data from randomised controlled trial. Materials 67 taking part a trial and who received analysed. Methods Platelet measured whole-blood flow cytometric measurement ADP-stimulated fibrinogen binding at baseline 12 h after administration loading dose 300 mg clopidogrel. Patients continued receive 75 mg daily for 30 days again day 30. Compliance treatment assessed by counting returned tablets. Results Six were excluded analysis because incomplete compliance treatment. sixty-one (9.8%) showed no reduction At these six still Amongst remaining 55 patients, mean 51.5% (95% CI: 43.8–59.2). responders there wide (range 8.11–97.7%). Four (6.6%) more than 95% binding. Conclusions show their While small proportion shows all, another group appears respond excessively Clinical studies are required identify whether hyper-responders increased risk bleeding complications hyporesponders higher thrombotic events.