The determined state of white expression in the Drosophila eye is modified by zeste1 in the wzm family of mutants.

摘要: Analysis of the white zeste mottled (wzm) mutant family suggests that zeste gene product functions in establishing and stabilizing a transcriptionally active chromatin domain for white locus expression. The z 1 mutation reduces expression paired or proximate copies white, while single unpaired maintain wildtype levels w zm mutation, caused by insertion retrotransposon BEL into 5′ intron alters zeste-white interaction to produce eye phenotype hemizygous z 1 w males. We have determined molecular structure four derivatives. zl results from an additional transposable element regulatory region white. w zvlis deletion sequences upstream locus. Two others, w haloand w cres, result transposition w zmplus entire verticals-roughest heterochromatin near tip chromosome 3L. They variegate roughest but not white; rather, effect on w zmnow causes become non-autonomous non-clonal. analysis these five mutations shows neomorphic zeste 1 product, combination with structural changes imposed transposons intercalary heterochromatin, modifies determination stability propose normal as part complex stimulates transcription changing conformation establish domains. unpairing homologs is proposed be one initial conformational change, providing explanation role transvection.