Cancer- and behavior-related genes are targeted by selection in the Tasmanian devil (Sarcophilus harrisii)
作者： Jean-Noël Hubert , Tatiana Zerjal , Frédéric Hospital
DOI: 10.1371/JOURNAL.PONE.0201838
关键词:
摘要: Devil Facial Tumor Disease (DFTD) is an aggressive cancer notorious for its rare etiology and impact on Tasmanian devil populations. Two regions underlying evolutionary response to this were recently identified using genomic time-series pre- post-DTFD arrival. Here, we support that DFTD shaped the genome of in even more extensive way than previously reported. We detected 97 signatures selection, including 148 protein coding genes having a human orthologue, linked DFTD. Most candidate are associated with progression, important subset has additional influence social behavior. This confirms ecology evolution devil. Our work also demonstrates possibility detect highly polygenic footprints short-term selection very small
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