Overinhibition of Mitogen.Activated Protein Kinase Inducing Tau Hyperphosphorylation
作者： Li Hong-lian , Chen Juan , Liu Shi-jie , Zhang Jia-yu , Wang Qun
DOI: 10.1007/BF02831155
关键词:
摘要: To reveal the relationship between mitogen-activated protein kinese (MAPK) and tau phosphorylation, we used different concentration of PD98059, an inhibitor MEK (MAPK kinase), to treat mice neuroblastma (N2a) cell line for 6 h. It showed that activity MAPK decreased in a dose-dependent manner. But Western blot immunofluorescence revealed just when cells were treated with 16 μmol/L was hyperphosphorylated at Ser396/404 Ser199/202 sites. We obtained conclusion overinhibited induced hyperphosphorylation
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