Ventilator-Associated Pneumonia, Endotracheal Tubes and Biofilms

作者: Steven L. Percival , David W. Williams

DOI: 10.1016/B978-0-12-397043-5.00012-8

关键词:

摘要: Endotracheal (ET) tubes are essential devices for maintaining the airway in mechanically ventilated patients and facilitating gaseous exchange. However, during use they can provide a surface development of biofilms, which contain potentially pathogenic micro-organisms. These micro-organisms may disseminate into patient’s lower airway, leading to ventilator-associated pneumonia (VAP). VAP significantly increases morbidity rate length patient stay intensive care. Evidence suggests that an improved understanding composition ET biofilm communities result preventative strategies VAP—in particular, impregnated with antimicrobials.

参考文章(52)
G Schultze-Werninghaus, R Ferrer, T T Bauer, K Rasche, A Torres, C M Heyer, Biofilm formation in endotracheal tubes. Association between pneumonia and the persistence of pathogens. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. ,vol. 57, pp. 84- 87 ,(2002)
Shashi K Murthy, Nanoparticles in modern medicine: state of the art and future challenges. International Journal of Nanomedicine. ,vol. 2, pp. 129- 141 ,(2007)
Alison Wilson, Dana Gray, Jacqueline Karakiozis, John Thomas, Advanced endotracheal tube biofilm stage, not duration of intubation, is related to pneumonia Journal of Trauma-injury Infection and Critical Care. ,vol. 72, pp. 916- 923 ,(2012) , 10.1097/TA.0B013E3182493A10
Lorenzo Berra, Francesco Curto, Gianluigi Li Bassi, Patrice Laquerriere, Andrea Baccarelli, Theodor Kolobow, Antibacterial-coated tracheal tubes cleaned with the Mucus Shaver : a novel method to retain long-term bactericidal activity of coated tracheal tubes. Intensive Care Medicine. ,vol. 32, pp. 888- 893 ,(2006) , 10.1007/S00134-006-0125-6
Emili Diaz, Alejandro H Rodríguez, Jordi Rello, None, Ventilator-associated pneumonia: issues related to the artificial airway. Respiratory Care. ,vol. 50, pp. 900- 909 ,(2005)
Ian G. Needleman, Nicholas P. Hirsch, Michele Leemans, David R. Moles, Michael Wilson, Derren R. Ready, Salim Ismail, Lena Ciric, Michael J. Shaw, Martin Smith, Anne Garner, Sally Wilson, Randomized controlled trial of toothbrushing to reduce ventilator-associated pneumonia pathogens and dental plaque in a critical care unit Journal of Clinical Periodontology. ,vol. 38, pp. 246- 252 ,(2011) , 10.1111/J.1600-051X.2010.01688.X
Merrill A. Biel, Chet Sievert, Marina Usacheva, Matthew Teichert, Eric Wedell, Nicolas Loebel, Andreas Rose, Ron Zimmermann, Reduction of endotracheal tube biofilms using antimicrobial photodynamic therapy Lasers in Surgery and Medicine. ,vol. 43, pp. 586- 590 ,(2011) , 10.1002/LSM.21103
T J Inglis, M R Millar, J G Jones, D A Robinson, Tracheal tube biofilm as a source of bacterial colonization of the lung. Journal of Clinical Microbiology. ,vol. 27, pp. 2014- 2018 ,(1989) , 10.1128/JCM.27.9.2014-2018.1989
Scott Cairns, John Gilbert Thomas, Samuel James Hooper, Matthew Peter Wise, Paul John Frost, Melanie Julia Wilson, Michael Alexander Oxenham Lewis, David Wynne Williams, None, Molecular Analysis of Microbial Communities in Endotracheal Tube Biofilms PLoS ONE. ,vol. 6, pp. e14759- ,(2011) , 10.1371/JOURNAL.PONE.0014759
Andrew F. Shorr, Marya D. Zilberberg, Marin Kollef, Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia. Infection Control and Hospital Epidemiology. ,vol. 30, pp. 759- 763 ,(2009) , 10.1086/599005