Antibacterial-coated tracheal tubes cleaned with the Mucus Shaver : a novel method to retain long-term bactericidal activity of coated tracheal tubes.

摘要: To assess the long-term benefit from antibacterial coatings of tracheal tube (ETT), and to keep clean lumen ETT. Experimental animal study. USA National Institutes Health. Twelve sheep. ETTs were internally dip-coated with a silver-sulfadiazine in polyurethane. We developed a concentric inflatable silicone rubber “razor”, Mucus Shaver (MS), shave ETT free mucus. In a single pass, we cleaned all mucus internal surface Control group: Five intubated sheep mechanically ventilated for 72 h. The was suctioned every 6 h. Study Six MS An additional 168 h. Bacteriologic studies scanning electron microscopy performed bacterial colonization thickness secretions on control group, always heavily colonized: median debris 380 μm, range 270–550 μm. study there no ETT, except three that colonized solely at very tip. Silver-based coating 6 h significantly reduces accumulation mucus/secretion growth within following 72 h mechanical ventilation.