In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise.

摘要: Epidemiological and experimental studies have shown increased frequency severity of infections after intense, long-term exercise. This study examines whether an in vivo impairment the cell-mediated immunity antibody production can be demonstrated Twenty-two male triathletes performed one-half ironman (group A). Vaccinations with tetanus diphtheritis toxoid purified pneumococcal polysaccharide were given Furthermore, a skin test seven different antigens was applied on forearm. Antibody titers measured before 2 wk The read 48 h application. Eleven non-exercising B) 22 moderately trained men C) used as control groups. Group A revealed significantly lower response to antigen than both groups B C. In group A, smaller cumulative (sum diameters indurations number positive spots) found No differences among three Thus, impaired first days prolonged, high intensity exercise, whereas there no vaccination.