Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease.

作者: Masako Murai , Hiroyuki Yoneyama , Akihisa Harada , Zhang Yi , Christian Vestergaard

DOI: 10.1172/JCI6642

关键词:

摘要: … These results suggest that MIP-1α–induced migration of CCR5-expressing CD8 + T cells into the portal areas of the liver plays a significant role in causing liver injury in GVHD; thus, …

参考文章(36)
S Qin, J B Rottman, P Myers, N Kassam, M Weinblatt, M Loetscher, A E Koch, B Moser, C R Mackay, The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. Journal of Clinical Investigation. ,vol. 101, pp. 746- 754 ,(1998) , 10.1172/JCI1422
James L.M. Ferrara, H. Joachim Deeg, Graft-versus-Host Disease New England Journal of Medicine. ,vol. 324, pp. 667- 674 ,(1991) , 10.1056/NEJM199103073241005
J. M. Vossen, C. Zurcher, P. J. Heidt, H. P. M. Brok, P. H. Van Der Meide, Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. Journal of Immunology. ,vol. 151, pp. 6451- 6459 ,(1993)
Raffaella Bonecchi, Giancarlo Bianchi, Paola Panina Bordignon, Daniele D'Ambrosio, Rosmarie Lang, Alessandro Borsatti, Silvano Sozzani, Paola Allavena, Patrick A. Gray, Alberto Mantovani, Francesco Sinigaglia, Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s Journal of Experimental Medicine. ,vol. 187, pp. 129- 134 ,(1998) , 10.1084/JEM.187.1.129
U E Gibson, C A Heid, P M Williams, A novel method for real time quantitative RT-PCR. Genome Research. ,vol. 6, pp. 995- 1001 ,(1996) , 10.1101/GR.6.10.995
M B Baker, N H Altman, E R Podack, R B Levy, The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. Journal of Experimental Medicine. ,vol. 183, pp. 2645- 2656 ,(1996) , 10.1084/JEM.183.6.2645
Joshua M. Farber, Mig and IP‐10: CXC chemokines that target lymphocytes Journal of Leukocyte Biology. ,vol. 61, pp. 246- 257 ,(1997) , 10.1002/JLB.61.3.246
Ruth D. Allen, Tabitha A. Staley, Charles L. Sidman, Differential cytokine expression in acute and chronic murine graft-versus-host-disease European Journal of Immunology. ,vol. 23, pp. 333- 337 ,(1993) , 10.1002/EJI.1830230205
Shao-bo Su, Naofumi Mukaida, Jian-bin Wang, Hideki Nomura, Kouji Matsushima, Preparation of specific polyclonal antibodies to a C-C chemokine receptor, CCR1, and determination of CCR1 expression on various types of leukocytes Journal of Leukocyte Biology. ,vol. 60, pp. 658- 666 ,(1996) , 10.1002/JLB.60.5.658