Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma

摘要: A role of heat shock protein 27 (HSP27) as a potential biomarker has been reported in various tumour entities, but comprehensive studies pancreatic cancer are lacking. Applying tissue microarray (TMA) analysis, we correlated HSP27 expression status with clinicopathologic parameters ductal adenocarcinoma specimens from 86 patients. Complementary, established overexpression and RNA-interference models to assess the impact on chemo- radiosensitivity directly cells. In TMA study, was found 49% samples. univariate analyses, significant correlation between survival. multivariate Cox-regression model, emerged an independent prognostic factor. also inversely nuclear p53 accumulation, indicating either interactions or TP53 mutation-dependent HSP27-regulation cancer. sensitivity studies, rendered low-expressing PL5 cells more susceptible towards treatment gemcitabine. Vice versa, depletion high-expressing AsPC-1 caused increased gemcitabine resistance. Importantly, inducible cell lines well primary Taken together, our study suggests for predictive marker Assessment could thus facilitate identification specific patient subpopulations that might benefit individualized options. Additional need clarify whether modulation represent attractive concept support incorporation hyperthermia clinical protocols