Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using Mendelian randomization
作者： Qingxian Huang , Jia Mi , Xizhen Wang , Fang Liu , Dan Wang
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摘要: ObjectivesTo undertake a systematic meta-analysis of all variants in the gene encoding receptor for advanced glycation end products (RAGE) to summarize their associations with cancer risk and changes levels circulating soluble RAGE (sRAGE), aim determining possible causality between sRAGE risk.MethodsArticles written English were retrieved from MEDLINE® EMBASE® databases. Two researchers independently identified eligible articles extracted data (analysed using STATA® software version 12.0).ResultsFifteen qualified inclusion RAGE–cancer association three examined RAGE–sRAGE relationship. The 82Ser/82Ser genotype was significantly associated overall compared 82Gly/Gly (odds ratio 1.75, 95% confidence interval [CI] 1.46, 2.10). Carriers had reduced concentrations 82Gly/82Gly genotype. Mende...
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