Contributory Role of Five Common Polymorphisms of RAGE and APE1 Genes in Lung Cancer among Han Chinese

摘要: Background Lung cancer is the leading cause of mortality in China. Given ubiquitous nature gene-to-gene interaction lung carcinogenesis, we sought to evaluate five common polymorphisms from advanced glycosylation end product-specific receptor (RAGE) and apurinic/apyrimidinic endonuclease 1 (APE1) genes association with among Han Chinese. Methods Results 819 patients 803 cancer-free controls were recruited Qiqihar city. Genotypes examined (RAGE gene: rs1800625, rs1800624, rs2070600; APE1 rs1760944, rs1130409) determined by ligase detection reaction method. Data analyzed R software multifactor dimensionality reduction (MDR). Hardy-Weinberg equilibrium was satisfied for all polymorphisms. Overall differences genotype allele distributions significant rs1800625 (Pgenotype<0.0005; Pallele<0.0005), rs2070600 (Pgenotype = 0.005; Pallele 0.004) rs1130409 0.009; Haplotype C-A-A (alleles order rs1800624 rs2070600) RAGE gene overrepresented patients, conferred a 2.1-fold increased risk (95% confidence interval: 1.52–2.91), independent confounding factors. Further application MDR method identified overall best model including This had maximal testing accuracy 64.63% cross-validation consistency 9 out 10 at level 0.006. Conclusions Our findings demonstrated potential interactive contribution pathogenesis Chinese. studies are warranted confirm or refute these findings.