The effect of the mouse X-linked Testicular feminization mutation on the hypothalamus-pituitary axis. I. Paradoxical effect of testosterone upon pituitary gonadotrophs.
作者： H. Itakura , S. Ohno
DOI: 10.1111/J.1399-0004.1973.TB01127.X
关键词:
摘要: Testosterone exercises a negative feedback upon pituitary gonadotrophs, paiticularly presumptive LH producers, of both the normal male and female mouse. In sharp contrast, effect testosterone corresponding cells Tfm/Y♂ can best be described as positive feedback. These Tfm/Y♀ atrophy after castration show remarkable hypertrophy in response to continuous administration testosterone.
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