The Role of Receptors in the Anabolic Action of Androgens
作者： C. WAYNE BARDIN , LESLIE P. BULLOCK , NATHANIEL C. MILLS , LIN YEN-CHIU , SAMSON T. JACOB
DOI: 10.1016/B978-0-12-526302-3.50009-5
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摘要: Publisher Summary The growth-promoting effect of testosterone and its 5 α -metabolites on the male reproductive tract is generally referred to as androgenic action this class steroids. By contrast, stimulatory these hormones body weight nitrogen balance termed their anabolic action. major extragenital site androgen skeletal muscle. However, magnitude response varies widely among individual muscles between species. kidney receptor heat labile can promote association with purified DNA. These properties in mouse are remarkably similar those accessory sexual tissue. This chapter presents studies that suggest androgens elicit initial nuclei by preferentially stimulating fractional activity RNA polymerase II. ability progestins mimic well recognized. demonstration progestational androgenicity highly dependent upon steroid end point used.
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