Cerebral Cortical Gray Expansion Associated with Two Second-Generation Antipsychotics

摘要: Background Second-generation antipsychotics (SGAs) differ from first-generation (FGAs) with respect to induction of less extrapyramidal morbidity, partially reducing negative symptoms, and causing modest improvement in neurocognitive functioning patients schizophrenia. SGAs demonstrate 5-HT2a antagonism. Differential effects FGAs on cortical gray volumes are explored herein. Methods Cerebral was examined volumetrically 19 schizophrenia before following 28 days treatment two (risperidone ziprasidone; n = 13) or a FGA (haloperidol; 6). Seven (untreated) control subjects were also assessed at similar interval. Results During the risperidone ziprasidone, cerebral 13 expanded 20.6 ± 11.4 cc ( p .983 .932, respectively) time reassessment. Conclusions Volumetric increase occurred early course ziprasidone risperidone, but not haloperidol. Such expansion may be relevant reported enhanced neurocognition quality life associated SGA treatment.