LDL-cholesterol, HDL-cholesterol or triglycerides—which is the culprit?

摘要: Dyslipidaemia in patients with type 2 diabetes commonly consists of elevated triglyceride levels; normal or slightly low-density lipoprotein (LDL)-cholesterol levels a preponderance small, dense LDL particles; and low high-density (HDL)-cholesterol HDL. These abnormalities are closely connected, prolonged residence high triglyceride-rich particles the circulation favoring Each these factors has been associated endothelial dysfunction; each contributes directly indirectly to atheroma formation, remnants increasing deposition cholesteryl ester vessel walls. This process is facilitated by reduced reverse cholesterol transport association HDL-cholesterol abnormal Lipid-lowering therapy focused on LDL-cholesterol reduction highly successful preventing coronary disease diabetic patients. Additional strategies for treating cluster risk dyslipidaemia necessary further reduce atherosclerotic this population.