Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic.

摘要: Background There are indications that Th1 polarization of immune response plays an important role in the pathogenesis recurrent aphthous stomatitis (RAS), and use probiotics can stimulate regulatory activity, influencing course disease. The aim this study was to characterize initial profile RAS patients evaluate clinical serological following a challenge with symbiotic treatment containing fructooligosaccharide, Lactobacillus, Bifidobacterium. Methods responses 45 RAS, submitted or placebo for 120 days, relation 30 RAS-free controls, were evaluated over period 6 months. Peripheral blood collected from all at 0 (T0), (T4), 180 days (T6) after start (IL12-p70, IFN-γ), Th2 (IL-4), Treg (IL-10), Th17 (IL-17A), inflammatory (TNF-α, IL-6)-associated cytokines, parameters quantified. Results At T0, significant differences found levels IFN-γ, IL-4, IL-6 cytokines comparison controls. It observed cytokine group comprised 2 distinct clusters: pure Mixed (Th1/Th2) subtype induced improvement pain increase IFN-γ levels, producing reduction response. Conclusions In based on Bifidobacterium composition produced alteration direction improved symptomatology.