Further observations on the immune response to recombinant hepatitis B vaccine after administration to aboriginal and Torres Strait Island children.

摘要: Objective: To determine the prevalence of markers hepatitis B virus (HBV) immunity and infection at 5 years age in Aboriginal Torres Strait Island children who were fully vaccinated infancy, to examine response a booster dose vaccine those had no detectable despite vaccination. Methodology: A cross-sectional study serological HBV sample 239 children, with mean 5.7 years, infancy. The antibody was determined either or HBV. Results: Of 6% (95% Cl 4–10%) been infected and, these, four surface antigen (HBsAg) positive. Of remaining 224 only 41% 35–48%) evidence (i.e. an (anti-HBs) level ≥10 miu/mL) HBV. anti-HBs < 10 miu/mL), 113 followed up after receiving vaccine. 84% 76–90%) anamnestic <10 miu/mL following dose). Therefore 16% 10–24%) still dose. Conclusions: This provides further that have suboptimal recombinant It also indicates considerable number cohort exposed However, these concerns, this historical data provide strong there has marked reduction carriage previously ‘high risk’ since introduction vaccines. infancy do not require school entry.