Association between an MHC Class II Allele and Clearance of Hepatitis B Virus in the Gambia
作者： Mark R. Thursz , Dominic Kwiatkowski , Catherine E.M. Allsopp , Brian M. Greenwood , Howard C. Thomas
DOI: 10.1056/NEJM199504203321604
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摘要: Background The course of hepatitis B virus (HBV) infection does not appear to be determined by variations in viral virulence and may influenced the host immune response. We studied distribution human leukocyte antigens children adult men Gambia who spontaneously recovered from HBV as compared with these subjects persistent infection. Methods In a two-stage, case –control study, we analyzed frequency MHC class I II haplotypes either transient or typing was performed microlymphocytotoxicity assays. analysis restriction-fragment–length polymorphisms (RFLPs), supplemented other techniques. Results first stage (the study up age 10 years), RFLP pattern 25-1, which includes allele HLA-DRB1*1302, found 58 218 (26.6 percen...
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