Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice

摘要: Transgenic mice that carry fusions between the transcriptional regulatory sequences of atrial natriuretic factor (a hormone intimately involved in regulation blood pressure) and those encoding SV40 T antigen (an oncoprotein) were generated. Although both atria express fusion gene, pathological response to is asymmetrical. The right atrium undergoes a several hundredfold increase mass while left remains relatively normal size. Hyperplasia accompanied by progressive frequency severity abnormalities conduction system, which ultimately result death.