Liquid biopsy of PIK3CA mutations in cervical cancer in Hong Kong Chinese women

摘要: Abstract Introduction Cervical cancer is the fourth most common female worldwide. The prognosis for women with advanced-stage or recurrent cervical remains poor and response to treatment variable. Standardized management protocols leave little room individualization. We report on a novel blood-based liquid biopsy specific PIK3CA mutations as clinically useful biomarker in patients invasive cancer. Methods One hundred seventeen Hong Kong Chinese primary their pre-treatment plasma samples were investigated. Two mutations, p.E542K p.E545K measured cell free DNA (cfDNA) extracted from using droplet digital PCR. This of was correlated clinico-pathological features verify potential molecular predicting disease monitoring progression. Results either p.E545K, detected cfDNA 22.2% patients. mutation status significantly median tumor size ( p associated decreased disease-free survival overall Conclusions As biopsy, analysis circulating shows promise way refine risk stratification individual cancer, provides platform further research offer individualized therapy purpose improving outcomes.