Возможности жидкостной биопсии в диагностике и мониторинге цервикального рака

作者: E. V. Kayukova

DOI: 10.21294/1814-4861-2019-18-2-92-101

关键词:

摘要: Cervical cancer is one of the most common cancers among women reproductive age. The cytological screening not always effective and appropriate, therefore search for new predictive markers cervical are great importance. there no biomarkers monitoring patients previously treated cancer. liquid biopsy a option personalized approach to detection it set methods determining derivatives tumor in biological media, often blood: circulating cells, dNa, RNa, exosomes, etc. purpose studywas analyze data on role diagnosis Material methods. We analyzed publications available from pubmed, Elibrary over past 10 years. Results. Circulating dNa exosomes studied non-invasive biomarkers. these play key understanding carcenogenesis, chemo-and radioresistance. currently, considered as promising modern method diagnostic efficiency this good, so can be used cervcal screening. However, such statements require further research direction. addition, given emerging information molecular carcinogenesis cancer, also basis development targeted therapy locally advanced generalized Conclusion. Liquid monitoring.

参考文章(54)
Luis Steven Servín-González, Angelica Judith Granados-López, Jesús Adrián López, Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer International Journal of Molecular Sciences. ,vol. 16, pp. 12773- 12790 ,(2015) , 10.3390/IJMS160612773
Tanja Fehm, Malgorzata Banys, Brigitte Rack, Bernadette Jäger, Andreas Hartkopf, Florin-Andrei Taran, Wolfgang Janni, Presence of disseminated tumor cells in bone marrow correlates with tumor stage and nodal involvement in cervical cancer patients International Journal of Cancer. ,vol. 134, pp. 925- 931 ,(2014) , 10.1002/IJC.28417
Malyn May Asuncion Valenzuela, Heather R. Ferguson Bennit, Amber Gonda, Carlos J. Diaz Osterman, Abby Hibma, Salma Khan, Nathan R. Wall, Exosomes Secreted from Human Cancer Cell Lines Contain Inhibitors of Apoptosis (IAP) Cancer Microenvironment. ,vol. 8, pp. 65- 73 ,(2015) , 10.1007/S12307-015-0167-9
Yuqing He, Juanjuan Lin, Yuanlin Ding, Guodong Liu, Yanhong Luo, Mingyuan Huang, Chengkai Xu, Taek-Kyun Kim, Alton Etheridge, Mi Lin, Danli Kong, Kai Wang, A systematic study on dysregulated microRNAs in cervical cancer development International Journal of Cancer. ,vol. 138, pp. 1312- 1327 ,(2016) , 10.1002/IJC.29618
Claudia Pfitzner, Isabel Schröder, Cornelia Scheungraber, Askin Dogan, Ingo Bernhard Runnebaum, Matthias Dürst, Norman Häfner, Digital-Direct-RT-PCR: a sensitive and specific method for quantification of CTC in patients with cervical carcinoma Scientific Reports. ,vol. 4, pp. 3970- 3970 ,(2015) , 10.1038/SREP03970
Maura Campitelli, Emmanuelle Jeannot, Martine Peter, Emmanuelle Lappartient, Stéphanie Saada, Anne de la Rochefordière, Virginie Fourchotte, Séverine Alran, Peter Petrow, Paul Cottu, Jean-Yves Pierga, Olivier Lantz, Jérôme Couturier, Xavier Sastre-Garau, Human Papillomavirus Mutational Insertion: Specific Marker of Circulating Tumor DNA in Cervical Cancer Patients PLoS ONE. ,vol. 7, pp. e43393- ,(2012) , 10.1371/JOURNAL.PONE.0043393
Cornelia Scheungraber, Bernhard Müller, Christhardt Köhler, Marc Possover, Sabine Leistritz, Achim Schneider, Matthias Dürst, Detection of disseminated tumor cells in patients with cervical cancer Journal of Cancer Research and Clinical Oncology. ,vol. 128, pp. 329- 335 ,(2002) , 10.1007/S00432-002-0340-7
Sacnite del Mar Díaz-González, Jessica Deas, Odelia Benítez-Boijseauneau, Claudia Gómez-Cerón, Victor Hugo Bermúdez-Morales, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza, Utility of microRNAs and siRNAs in cervical carcinogenesis. BioMed Research International. ,vol. 2015, pp. 374924- 374924 ,(2015) , 10.1155/2015/374924
Keimari Mendez, Josefina Romaguera, Ana P. Ortiz, Mariel López, Martin Steinau, Elizabeth R. Unger, Urine-based human papillomavirus DNA testing as a screening tool for cervical cancer in high-risk women International Journal of Gynecology & Obstetrics. ,vol. 124, pp. 151- 155 ,(2014) , 10.1016/J.IJGO.2013.07.036
Dieter J.E. Peeters, Anja Brouwer, Gert G. Van den Eynden, Annemie Rutten, Wendy Onstenk, Anieta M. Sieuwerts, Steven J. Van Laere, Philippe Huget, Patrick Pauwels, Marc Peeters, Peter B. Vermeulen, Luc Y. Dirix, Circulating tumour cells and lung microvascular tumour cell retention in patients with metastatic breast and cervical cancer. Cancer Letters. ,vol. 356, pp. 872- 879 ,(2015) , 10.1016/J.CANLET.2014.10.039