Utility of microRNAs and siRNAs in cervical carcinogenesis.
作者： Sacnite del Mar Díaz-González , Jessica Deas , Odelia Benítez-Boijseauneau , Claudia Gómez-Cerón , Victor Hugo Bermúdez-Morales
DOI: 10.1155/2015/374924
关键词:
摘要: MicroRNAs and siRNAs belong to a family of small noncoding RNAs which bind through partial sequence complementarity 3′-UTR regions mRNA from target genes, resulting in the regulation gene expression. have become an attractive for genetic pharmacological modulation due critical function their proteins several signaling pathways, expression profiles been found be altered various cancers. A promising technology platform selective silencing cell and/or viral using is currently development. Cervical cancer most common women developing world sexually transmitted infection with HPV cause this malignancy. Therefore, cascade abnormal events induced during cervical carcinogenesis, including induction genomic instability, reprogramming cellular metabolic deregulation proliferation, inhibition apoptotic mechanisms, disruption cycle control alteration Thus, present review article, we highlight new research on microRNA may utilized as biomarkers cancer. Furthermore, discuss E6 E7 represents potential therapy strategy against
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