The effect of smoking on serum progesterone, estradiol, and luteinizing hormone levels over a menstrual cycle in normal women.

摘要: Since smoking has been shown to affect serum progesterone and estradiol levels in postmenopausal women, we evaluated the of these hormones luteinizing hormone (LH) over an entire menstrual cycle (17 points) eight healthy nonsmokers smokers. The total length lengths follicular luteal phases did not differ between groups. There was no difference estradiol, progesterone, or LH during periovulatory phases. Follicular-phase which had a level 37% higher smokers, showed plateau both groups (28.3 +/- 5.7 ng/dl versus 20.7 5.7; P less than 0.0001). rising curve mean value smokers slightly that (107 pg/ml 95; approximately 0.05); early part phase, prior rapid preovulatory increase, greater (23%) statistical significance (80 65; 0.001). follicular-phase were skewed downward from nonsmokers, presumably by negative feedback elevated levels; significant (P elevations probably represent activation adrenocortical secretion smoking. more clear-cut rise is due fact essentially all secreted adrenal, while only comes adrenal (via androstenedione estrone).