Direct haplotyping of kilobase-size DNA using carbon nanotube probes.
作者： Adam T. Woolley , Chantal Guillemette , Chin Li Cheung , David E. Housman , Charles M. Lieber
DOI: 10.1038/77760
关键词:
摘要: We have implemented a method for multiplexed detection of polymorphic sites and direct determination of haplotypes in 10-kilobase-size DNA fragments using single-walled carbon nanotube (SWNT) atomic force microscopy (AFM) probes. Labeled oligonucleotides are hybridized specifically to complementary target sequences in template DNA, and the positions of the tagged sequences are detected by direct SWNT tip imaging. We demonstrated this concept by detecting streptavidin and IRD800 labels at two different …
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