Pathogenicity and complete genome sequence of a fowl adenovirus serotype 8 isolate.

摘要: In this study we determined and analyzed the complete nucleotide sequence of genome a fowl adenovirus serotype 8 (FAdV-8) isolate examined its pathogenicity in chickens. The full FAdV-8 was 44,055 nucleotides length with similar organization to that FAdV-1 FAdV-9 genomes. No regions homologous early E1, E3 E4 mastadenoviruses were recognized. Along FAdV-9, has only one fiber gene regard composition organization, is closer than FAdV-1. Moreover, our findings suggest species Fowl A as current type despite historical priority not representative genus Aviadenovirus, or E D, respectively, would be more suitable for designation. Additionally, studied specific pathogen free chickens following oral intramuscular inoculations. Despite lack clinical signs pathological changes virus found tissues cloacal swabs all birds highest viral copy numbers present cecal tonsils. titers feces orally intramuscularly inoculated recorded at days 10 3 post-infection, respectively.