Gastric cancer-derived exosomes promote peritoneal metastasis by destroying the mesothelial barrier.
作者： Guang Deng , Jinglei Qu , Ye Zhang , Xiaofang Che , Yu Cheng
关键词:
摘要: An intact mesothelium serves as a protective barrier to inhibit peritoneal carcinomatosis. Cancer-derived exosomes can mediate directional tumor metastasis; however, little is known about whether gastric cancer-derived will destroy the mesothelial and promote dissemination. Here, we demonstrate that facilitate metastasis by causing disruption fibrosis. Injury of cells elicited through concurrent apoptosis mesothelial-to-mesenchymal transition (MMT). Additionally, upregulation p-ERK in primarily responsible for MMT while contributing apoptosis. Together, these data support concept play crucial role remodeling premetastatic microenvironment identify novel mechanism carcinoma.
sci-hub.se 参考文章(52)
Steven E. Mutsaers, Sylwia Wilkosz, Structure and Function of Mesothelial Cells Cancer treatment and research. ,vol. 134, pp. 1- 19 ,(2007) , 10.1007/978-0-387-48993-3_1
Yu Sun, Wen-Zhou Liu, Tao Liu, Xu Feng, Nuo Yang, Hua-Fu Zhou, Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis Journal of Receptors and Signal Transduction. ,vol. 35, pp. 600- 604 ,(2015) , 10.3109/10799893.2015.1030412
Bruno Costa-Silva, Nicole M. Aiello, Allyson J. Ocean, Swarnima Singh, Haiying Zhang, Basant Kumar Thakur, Annette Becker, Ayuko Hoshino, Milica Tešić Mark, Henrik Molina, Jenny Xiang, Tuo Zhang, Till-Martin Theilen, Guillermo García-Santos, Caitlin Williams, Yonathan Ararso, Yujie Huang, Gonçalo Rodrigues, Tang-Long Shen, Knut Jørgen Labori, Inger Marie Bowitz Lothe, Elin H. Kure, Jonathan Hernandez, Alexandre Doussot, Saya H. Ebbesen, Paul M. Grandgenett, Michael A. Hollingsworth, Maneesh Jain, Kavita Mallya, Surinder K. Batra, William R. Jarnagin, Robert E. Schwartz, Irina Matei, Héctor Peinado, Ben Z. Stanger, Jacqueline Bromberg, David Lyden, Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver Nature Cell Biology. ,vol. 17, pp. 816- 826 ,(2015) , 10.1038/NCB3169
Pilar Sandoval, Jose Antonio Jiménez-Heffernan, Ángela Rynne-Vidal, María Luisa Pérez-Lozano, Álvaro Gilsanz, Vicente Ruiz-Carpio, Raquel Reyes, Julio García-Bordas, Konstantinos Stamatakis, Javier Dotor, Pedro L Majano, Manuel Fresno, Carlos Cabañas, Manuel López-Cabrera, Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis The Journal of Pathology. ,vol. 231, pp. 517- 531 ,(2013) , 10.1002/PATH.4281
Shinichi Kaneshima, Yoshito Kiyasu, Shigemasa Koga, Morphogenesis of Peritoneal Metastasis in Human Gastric Cancer Cancer Research. ,vol. 41, pp. 1236- 1239 ,(1981)
Ayuko Hoshino, Bruno Costa-Silva, Tang-Long Shen, Goncalo Rodrigues, Ayako Hashimoto, Milica Tesic Mark, Henrik Molina, Shinji Kohsaka, Angela Di Giannatale, Sophia Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, Kunihiro Uryu, Lindsay Pharmer, Tari King, Linda Bojmar, Alexander E. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, Kimberly Kramer, Leonard H. Wexler, Aru Narendran, Gary K. Schwartz, John H. Healey, Per Sandstrom, Knut Jørgen Labori, Elin H. Kure, Paul M. Grandgenett, Michael A. Hollingsworth, Maria de Sousa, Sukhwinder Kaur, Maneesh Jain, Kavita Mallya, Surinder K. Batra, William R. Jarnagin, Mary S. Brady, Oystein Fodstad, Volkmar Muller, Klaus Pantel, Andy J. Minn, Mina J. Bissell, Benjamin A. Garcia, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina Matei, Hector Peinado, Jacqueline Bromberg, David Lyden, Tumour exosome integrins determine organotropic metastasis Nature. ,vol. 527, pp. 329- 335 ,(2015) , 10.1038/NATURE15756
Zhi-Feng Miao, Ting-Ting Zhao, Zhen-Ning Wang, Feng Miao, Ying-Ying Xu, Xiao-Yun Mao, Jian Gao, Jian-Hua Wu, Xing-Yu Liu, Yi You, Hao Xu, Hui-Mian Xu, Transforming growth factor-beta1 signaling blockade attenuates gastric cancer cell-induced peritoneal mesothelial cell fibrosis and alleviates peritoneal dissemination both in vitro and in vivo Tumor Biology. ,vol. 35, pp. 3575- 3583 ,(2014) , 10.1007/S13277-013-1472-X
R M Heath, D G Jayne, R O'Leary, E E Morrison, P J Guillou, Tumour-induced Apoptosis in Human Mesothelial Cells: A Mechanism of Peritoneal Invasion by Fas Ligand/Fas Interaction British Journal of Cancer. ,vol. 90, pp. 1437- 1442 ,(2004) , 10.1038/SJ.BJC.6601635
Miranda Y. Fong, Weiying Zhou, Liang Liu, Aileen Y. Alontaga, Manasa Chandra, Jonathan Ashby, Amy Chow, Sean Timothy Francis O’Connor, Shasha Li, Andrew R. Chin, George Somlo, Melanie Palomares, Zhuo Li, Jacob R. Tremblay, Akihiro Tsuyada, Guoqiang Sun, Michael A. Reid, Xiwei Wu, Piotr Swiderski, Xiubao Ren, Yanhong Shi, Mei Kong, Wenwan Zhong, Yuan Chen, Shizhen Emily Wang, Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis Nature Cell Biology. ,vol. 17, pp. 183- 194 ,(2015) , 10.1038/NCB3094
Evette S. Radisky, Derek C. Radisky, Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer Journal of Mammary Gland Biology and Neoplasia. ,vol. 15, pp. 201- 212 ,(2010) , 10.1007/S10911-010-9177-X