Procancerogenic activity of senescent cells: A case of the peritoneal mesothelium.
作者： Justyna Mikuła-Pietrasik , Łukasz Stryczyński , Paweł Uruski , Andrzej Tykarski , Krzysztof Książek
DOI: 10.1016/J.ARR.2018.01.002
关键词:
摘要: Human peritoneal mesothelial cells belong to a narrow group of somatic in which both the triggers and mechanisms senescence have already been well defined. Importantly, senescent found cavity vivo. From clinical point view, recognized as playing critical role intraperitoneal development tumor metastases. The pro-cancerogenic behavior is even more pronounced when exhaust their proliferative capacity become senescent. In this review, we summarize current state art regarding contribution progression ovarian, colorectal, pancreatic carcinomas, with particular attention paid cancer-promoting activity counterparts. Moreover, delineate mechanisms, mediators, signaling pathways that are engaged by support such vital elements cancer adhesion, proliferation, migration, invasion, epithelial-mesenchymal transition, angiogenesis. Finally, discuss experimental evidence natural synthetic compounds may either prevent or restrict delaying cells.
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