Induction of neuronal apoptosis by expression of Hes6 via p53-dependent pathway.
作者： Bokkee Eun , Bongki Cho , Younghye Moon , Soo Young Kim , Kyungjin Kim
DOI: 10.1016/J.BRAINRES.2009.11.078
关键词:
摘要: Abstract Hes6 is a member of hairy/enhancer split (Hes) family that plays role in the cell proliferation and differentiation. Recently, we found involved regulation via p53-dependent pathway. In addition to proliferating regions, brain regions where early post-mitotic neurons are enriched also exhibited p53 mRNA expression. Because neuronal apoptosis, here investigated whether can influence survival/death. Overexpression wild-type its mutants induced apoptosis primary cultured cortical neurons. addition, by overexpression was markedly blunted −/− or Bax neurons, suggesting these pro-apoptotic effects mediated p53- Bax-dependent However, transactivation-defective enhanced apoptogenic activity not directly related transcriptional regulation. We propose may play significant death and/or pathological neurodegeneration activation signaling.
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