Hydrogen sulfide and neuronal differentiation: Focus on Ca2+ channels

摘要: Hydrogen sulfide (H2S) is considered the third gasotransmitter following nitric oxide (NO) and carbon monoxide (CO) in mammalian body including brain, heart, blood vessels, liver, kidney, pancreas, lung, gastrointestinal tract reproductive organs. H2S formed endogenously from L-cysteine by multiple enzymes, such as cystathionine-γ-lyase, cystathionine-β-synthase 3-mercaptopyruvate sulfurtransferase combination with cysteine aminotransferase, participates a variety of biological events through number target molecules. Exogenous and/or endogenous enhances activity T-type Ca(2+) channels NG108-15 cells isolated dorsal root ganglion neurons that abundantly express Cav3.2, Cav3.2-transfected HEK293 cells. Cav3.2 mediates not only H2S-induced enhancement pain signals nociceptor neurons, but also neuronal differentiation characterized neuritogenesis functional upregulation high voltage-activated In this review, we focus on modulation primarily molecular mechanisms underlying differentiation.