Influence of anti cancer agents on growth migration and invasion of malignant fibroblastic cells
作者： G. Storme , M. Mareel
DOI: 10.1016/B978-0-08-025534-7.50016-1
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摘要: ABSTRACT The effect of 5-fluorouracil, ionizing radiation and the microtubular inhibitor nocodazole on growth directional migration virally transformed malignant C3H mouse fibroblastic cells (MO4) is compared with their invasiveness these in vitro. increase diameter individual aggregates MO4 shaker culture used as an index growth. mean circular area covered by migrating from aggregate explanted glass migration. Invasion studied using confrontations precultured fragments embryonic chick heart culture. Ionizing (5000 R) 5-fluorouracil (1 μg/ml) permit invasion for at least 14 days after onset treatment, although they inhibit microtubule-inhibitor inhibits prevents both invasion. We conclude that various anti-cancer agents, doses growth, have different effects suggest assay screening potential anti-invasive agents.
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