microRNA: The Impact on Cancer Stemness and Therapeutic Resistance.

摘要: Cancer ranks as the second leading cause of death worldwide, causing a large social and economic burden. However, most anti-cancer treatments face problems tumor recurrence metastasis. Therefore, finding an effective cure for cancer needs to be solved urgently. Recently, discovery stem cells (CSCs) provides new orientation research therapy. CSCs share main characteristics with are able generate entire tumor. Besides, usually escape from current therapies, which is partly responsible poor prognosis. microRNAs (miRNAs) belong small noncoding RNA regulate gene post-transcriptional expression. The dysregulation miRNAs leads plenty diseases, including cancer. aberrant miRNA expression in enhances stemness maintenance. In this review, we summarize role on eight common cancers, hoping bridge clinical applications. We found that can act promoter or suppressor. cell contributes metastasis therapeutic resistance via formation feedback loops constitutive activation carcinogenic signaling pathways. More importantly, some may potential targets diagnosis, prognosis, treatments.