GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression.
作者： Narasimhaswamy S Belaguli , Muhammad Aftab , Mohammed Rigi , Mao Zhang , Daniel Albo
DOI: 10.1593/NEO.10224
关键词: Plasminogen activator 、 GATA6 、 Zinc finger transcription factor 、 Biology 、 Cancer research 、 Regulatory sequence 、 Small interfering RNA 、 Gene knockdown 、 Gene 、 Gene expression 、 Molecular biology
摘要: … GATA6 in colon cancers and investigated the mechanisms by which GATA6 regulates colon cancer … more invasive colon cancer cell lines, we examined whether GATA6 regulates uPA …
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C. Nerlov, D. De Cesare, F. Pergola, A. Caracciolo, F. Blasi, M. Johnsen, P. Verde, A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. The EMBO Journal. ,vol. 11, pp. 4573- 4582 ,(1992) , 10.1002/J.1460-2075.1992.TB05559.X
Soichi Kojima, Kentaro Shimokado, Scott L. Friedman, Yasuhiro Suzuki, Massimo P. Crippa, Shinichi Hayashi, Jun Shimada, Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-β1 in vascular endothelial cells Blood. ,vol. 95, pp. 1309- 1316 ,(2000) , 10.1182/BLOOD.V95.4.1309.004K05_1309_1316
Erik T. Kimchi, Mitchell C. Posner, James O. Park, Thomas E. Darga, Masha Kocherginsky, Theodore Karrison, John Hart, Kerrington D. Smith, James J. Mezhir, Ralph R. Weichselbaum, Nikolai N. Khodarev, Progression of Barrett's Metaplasia to Adenocarcinoma Is Associated with the Suppression of the Transcriptional Programs of Epidermal Differentiation Cancer Research. ,vol. 65, pp. 3146- 3154 ,(2005) , 10.1158/0008-5472.CAN-04-2490
Mark D. Iannettoni, Mark B. Orringer, Matthew Schipper, Lin Lin, Charles T. Miller, David G. Beer, Daniel Normolle, Justin R. Moy, Dean E. Brenner, Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. Clinical Cancer Research. ,vol. 9, pp. 4819- 4825 ,(2003)
C Caslini, C D Capo-chichi, I H Roland, E Nicolas, A T Yeung, X-X Xu, Histone modifications silence the GATA transcription factor genes in ovarian cancer. Oncogene. ,vol. 25, pp. 5446- 5461 ,(2006) , 10.1038/SJ.ONC.1209533
Hanna Haveri, Mia Westerholm-Ormio, Katri Lindfors, Markku Mäki, Erkki Savilahti, Leif C Andersson, Markku Heikinheimo, Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa BMC Gastroenterology. ,vol. 8, pp. 9- 9 ,(2008) , 10.1186/1471-230X-8-9
Frédéric Charron, George Tsimiklis, Mathieu Arcand, Lynda Robitaille, Qiangrong Liang, Jeffery D Molkentin, Sylvain Meloche, Mona Nemer, Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes & Development. ,vol. 15, pp. 2702- 2719 ,(2001) , 10.1101/GAD.915701
Massimo P. Crippa, Urokinase-type plasminogen activator The International Journal of Biochemistry & Cell Biology. ,vol. 39, pp. 690- 694 ,(2007) , 10.1016/J.BIOCEL.2006.10.008
Toshiaki Mano, Zhengyu Luo, Slawomir L. Malendowicz, Todd Evans, Kenneth Walsh, Reversal of GATA-6 Downregulation Promotes Smooth Muscle Differentiation and Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery Circulation Research. ,vol. 84, pp. 647- 654 ,(1999) , 10.1161/01.RES.84.6.647
P. Verde, S. Boast, A. Franze, F. Robbiati, F. Blasi, An upstream enhancer and a negative element in the 5′ flanking region of the human urokinase plasminogen activator gene Nucleic Acids Research. ,vol. 16, pp. 10699- 10716 ,(1988) , 10.1093/NAR/16.22.10699