2'-O-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides

摘要: Disclosed are O -protected compounds of the formula (I):wherein B is an optionally protected nucleobase, and R 1 -R 3 as described herein, a method preparing such compounds, oligonucleotides RNA starting from compounds. The have one or more advantages, for example, 2'- compound stable during various reaction steps involved in oligonucleotide synthesis; protecting group can be easily removed after synthesis oligonucleotide, by with tetrabutylammonium fluoride; and/or groups do not generate DNA/RNA alkylating side products, which been reported removal -(2-cyanoethyl)oxymethyl -[2-(4-tolylsulfonyl)ethoxymethyl under similar conditions.