Vitamin D and diabetic nephropathy: A systematic review and meta-analysis.

摘要: Abstract Objective There has been a long history documenting the use of different vitamin D derivatives as therapy for renal diseases. However, to our knowledge, there is no comprehensive assessment relation between deficiency and risk diabetic nephropathy (DN). Additionally, effect supplementation on DN still unclear. The aim this meta-analysis was assess these issues by pooling together results from cross-sectional studies clinical trials. Methods A systematic literature search PubMed, Scopus, Google Scholar conducted, ending in September 2014. For studies, odds ratio used measure association status DN; trials, mean SD main outcome (urine albumin-to-creatinine [UACR]) intervention placebo groups were considered analysis. Results final selected articles published 2009 In all, 3700 219 patients enrolled observational interventional respectively. pooled six 1.80 (95% confidence interval [CI], 1.25–2.59; P  = 0.002), indicating significant inverse serum with diabetes. data UACR levels trials suggested change following (17.98; 95% CI, –35.35 71.32;  = 0.51). Conclusion This showed higher D–deficient Pooling available after did not support causality association.