No Evidence for Activated Autophagy in Left Ventricular Myocardium at Early Reperfusion with Protection by Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting
作者： Nilgün Gedik , Matthias Thielmann , Eva Kottenberg , Jürgen Peters , Heinz Jakob
DOI: 10.1371/JOURNAL.PONE.0096567
关键词:
摘要: Objective Remote ischemic preconditioning (RIPC) by repeated brief limb ischemia/reperfusion reduces myocardial injury in patients undergoing coronary artery bypass grafting (CABG). Activation of signal transducer and activator transcription 5 (STAT5) left ventricular (LV) myocardium at early reperfusion is associated with such protection. Autophagy, i.e., removal dysfunctional cellular components through lysosomes, has been proposed as one mechanism cardioprotection. Therefore, we analyzed whether or not the protection RIPC activated autophagy.
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