The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
作者： Elisabeth Schrumpf , Xiaojun Jiang , Sebastian Zeissig , Marion J. Pollheimer , Jarl Andreas Anmarkrud
DOI: 10.14814/PHY2.13117
关键词:
摘要: Natural killer T (NKT) cells are activated by lipid antigens presented CD1d molecules and represent a major lymphocyte subset of the liver. NODc3c4 mice spontaneously develop biliary inflammation in extra- intrahepatic bile ducts. We demonstrated flow cytometry that invariant NKT (iNKT) were more abundant thymus, spleen, liver compared to NOD mice. iNKT displayed an phenotype. Further, NODCd1d-/- irradiated injected with bone marrow, injection marrow resulted infiltrates independently expression recipient Activation or blocking α-galactosylceramide anti-CD1d antibody injections did not affect phenotype NODc3c4.Cd1d-/- generated crossing onto background. developed same extent disease. This study demonstrates model. The portal can be transferred recipients, which suggests immune-driven Our findings imply potentially participate inflammation, but primary drivers disease
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