The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?
作者： Daniel S. Smyk , Athanasios Mavropoulos , Giorgina Mieli-Vergani , Diego Vergani , Marco Lenzi
DOI: 10.1155/2018/8197937
关键词:
摘要: Natural killer T (NKT) cells are a distinct lineage of which express both the cell receptor (TCR) and natural (NK) markers. Invariant NKT (iNKT) bear an invariant TCR recognize small variety glycolipid antigens presented by CD1d (nonclassical MHC-I). CD1d-restricted iNKT regulators immune responses produce cytokines that may be proinflammatory (such as interferon-gamma (IFN-γ)) or anti-inflammatory IL-4). also appear to play role in B regulation antibody production. Alpha-galactosylceramide (α-GalCer), derivative marine sponge, is potent stimulator has been proposed therapeutic activator. have implicated development perpetuation several autoimmune diseases such multiple sclerosis systemic lupus erythematosus (SLE). Animal models SLE shown abnormalities numbers function, inverse correlation between frequency IgG levels observed. The liver disease (AiLD) not extensively studied. This review discusses current data with regard function AiLD, addition providing overview other conditions animal models. We discuss regarding immunomodulatory effects vitamin D on cells, serve potential target, given deficiencies reported various disorders.
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